Melanocortin Receptor 4 Signaling Regulates Vertebrate Limb Regeneration
نویسندگان
چکیده
منابع مشابه
Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth.
apterous specifies dorsal cell fate and directs outgrowth of the wing during Drosophila wing development. Here we show that, in vertebrates, these functions appear to be performed by two separate proteins. Lmx-1 is necessary and sufficient to specify dorsal identity and Lhx2 regulates limb outgrowth. Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does ...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2018
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2018.07.021